EICESS 92 (European Intergroup Cooperative
Ewing's Sarcoma Study) - Erste Ergebnisse
期刊名称： Klinische Pädiatrie
作者： H K Schackert,S Krüger,H Görgens,R Höhl,J Plaschke,S Pistorius,H.-D
Saeger
年份： 1999年
期号： 第04期
关键词： Ewing tumors;treatment;toxicity;secondary malignancies;outcome
摘要：BACKGROUND: Ewing tumor patients' outcome is 50% to 60% with current treatment strategies. Questions concerning toxicity and secondary malignancies are of increasing importance. PATIENTS AND METHODS: 631 patients were registered with the German EICESS study center of the
European Intergroup Cooperative Ewing's Sarcoma Study, 369 patients were randomized. Treatment apart from local therapy consisted of 14 courses of Vincristine, Actinomycin D, Cyclophosphamide or Ifosfamide, Adriamycin (Doxorubicin), with or without Etoposide. First results concerning event-free survival (EFS), toxicity, and the rate of secondary malignancies three years after diagnosis are presented. RESULTS: Three year EFS was 0.66 for patients with localized tumors, 0.43 for patients with primary pulmonary/ pleural metastases, and 0.29 for patients
cooperative
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