专利名称：Modulation of Cellular Migration
发明人：Harald W. Sontheimer,Vedrana Montana Parpura
申请号：US14008979modulate
申请日：20120330
公开号：US20140248291A1
公开日：
20140904
专利内容由知识产权出版社提供
摘要：Methods, kits, and compositions are provided for addressing cancer through the interaction of bradykinin (BK) and the bradykinin-2-receptor (B2R). This interaction controls cellular invasion, as has been unexpectedly observed in glioma cells, A composition is provided for the treatment of cancer by disrupting this interaction using an inhibitor or BK or B2R that can. be administered to the subject. Diagnostic processes are provided, involving measuring levels of BK or B2R to determine the potential for cancer (or to determine the invasive potential of a given cancer). Modulators of BK. and B2R may be used to modulate cellular migration, both in vivo and in vitro. Potential modulators of cellular migration can be screened by measuring the effect of the potential modulator on BK or B2R,
申请人：THE UAB RESEARCH FOUNDATION
地址：Birmingham AL US
国籍：US
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