The nuts and bolts of the platelet release reaction 期刊名称： Platelets
作者： Smita Joshi,Sidney W Whiteheart
年份： 2017年
期号： 第2期
关键词： Exocytosis;Munc13;Munc18;Rab;SNAREs;STXBP5
摘要：Secretion is essential to many of the roles that platelets play in the vasculature, e.g., thrombosis, angiogenesis, and inflammation, enabling platelets to modulate the microenvironment at sites of vascular lesions with a myriad of bioactive molecules stored in their granules. Past studies demonstrate that granule cargo release is mediated by Soluble NSF Attachment Protein Receptor (SNARE) proteins, which are required for granule-plasma membrane fusion. Several SNARE regulators, which control when, where, and how the SNAREs interact, have been identified in platelets. Additionally, platelet SNAREs are controlled by post-translational modifications, e.g., phosphorylation a
nd acylation. Although there have been many recent insights into the mechanisms of platelet secretion, many questions remain: have we identified all modulate
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