Relative and absolute stereochemistry of quinadoline B, an inhibitor of lipid droplet synthesis
in macrophages.
期刊名称： Organic Letters
作者： Koyama, Nobuhiro, Inoue, Yusuke, Sekine, Masae, Hayakawa, Yoichi,
Homma, Hiroshi, O?mura, Satoshi, Tomoda, Hiroshi
年份： 2008年
期号： 第22期
关键词： Animals;Mice;Macrophages;Heterocyclic Compounds, 3-
Ring;Lipids;Magnetic Resonance Spectroscopy;Aspergillus;Stereoisomerism
摘要：New fungal metabolites, designated quinadolines A (1) and B (2), were isolated from culture brot
h of Aspergillus sp. FKI-1746, and their structures were elucidated by NMR spectroscopy. The complete relative and absolute stereochemistry of 2 was determined by X-ray crystallography and amino acid analysis using a chiral column. Quinadolines moderately inhibited lipid droplet synthesis in mouse macrophages.
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