Pathophysiology of DIC in obstetric disorders
产科DIC的病理生理学characterise
It is important to understand the normal coagulation process in order to characterise the abnormalities observed during DIC.
为了描述DIC的异常特征，理解正常的凝血过程十分重要。
1. The coagulant response begins with exposure of tissue factor (TF) and binding of factor VIIa to activate factor X for conversion of pro-thrombin to thrombin.[1]
凝血反应始于组织因子（TF）的暴露以及VIIa与Xa结合使凝血酶原转变为凝血酶[1]。
2. Thrombin generation is further propagated through the intrinsic pathway and the explosive burst of thrombin results in cleavage of fibrinogen into fibrin.[2]
凝血酶通过内源性途径进一步生成，凝血酶的爆发式生成导致了纤维蛋白原裂解为纤维蛋白[2]。
3. Clot formation is homeostatically regulated to achieve the desired haemostatic effect and this involves a number of regulatory responses that are spatially and temporally differentiated.
血块的形成是自稳性调节而获得理想的止血效果，这涉及了大量的时空特异性的调解节反应。
4. Normal endothelium at the margins of injury switches from thrombin procoagulant to anticoagulant activity via its binding to the endothelial receptor, thrombomodulin (TM).[3]

版权声明：本站内容均来自互联网，仅供演示用，请勿用于商业和其他非法用途。如果侵犯了您的权益请与我们联系QQ:729038198，我们将在24小时内删除。