profile中文天津⼤学《制药⼯艺学》中英⽂对译
pharmaceutical technology制药⼯工艺学pharmaceutical pipeline制药链pharmacopoeia药典。Roswell Park Memorial Instirute RPMI good manufacturing practices for drugs GMP制药⾏行行业
medicines，drugs药品traditional Chinese medicines中药natural medicines天然药物chemical drugs化学药物
biologics，biologic products⽣生物制品generics，generic drugs仿制药物
me-too-drug仿制药biosimilars⽣生物类似药biotechnology⽣生物技术.Food and druge administration FDA biotechnology pharmaceutical，biopharmaceutical⽣生物制药
nucleotide核苷酸nucleoside核⽢甘
enzyme酶enzyme inhibitor酶抑制剂immunomodulator免疫调节剂penicillin⻘青霉素
antibody engineering抗体⼯工程inducer诱导剂
precursor前体prodrug前药
transformation遗传转化.conversion⽣生物转化
fermentation发酵.strain breeding菌种选育
separation and purification分离纯化和提纯.cell growth phase/fermentation
product synthesis phase/product secretion phase.Murashige&Skoog MS
cell autolysis phase/ic通⽤用药物
metabolism代谢.substrate培养基质
primary/secondary metabolism初级/次级代谢.specific growth rate⽐比⽣生⻓长速率
lag/log/decline/stationary/death phase延滞期/对数⽣生⻓长期/减数期/稳定期/死亡期
coupling model⽣生⻓长与⽣生产偶联型.PEG聚⼄乙⼆二醇
semi-coupling model⽣生⻓长与⽣生产半偶联型.starter culture培养物
non-coupling model⽣生⻓长与⽣生产⾮非偶联型.storage保存
protoplast fusion原⽣生质体融合.DMSO⼆二甲基亚砜
master stock/cell bank MSB/MCB主菌种库.glycerol⽢甘油
working stock/cell bank WSB/WCB⼯工作菌种库.Streptomyces链霉菌
quality control QC质量量控制.cholramphenicol氯霉素
China Center for Type Culture Collection CCTCC中国典型培养物保藏中⼼心
China General Microbiological Culture Collection Center CGMCC中国普通微⽣生物保藏管理理中⼼心
China Center of Industrial Culture Collection CICC中国⼯工业微⽣生物菌种保藏管理理中⼼心National Center for Medical Culture Collection（Bacteria）CMCC中国医学微⽣生物菌种保藏中⼼心
America Type Culture Collection ATCC
European Collection of Cell Culture ECACC
Institure for Fermentation，Osaka IFO
National Collection of Type Culture mNCTC
medium培养基.carbon source碳源
nitrogen source氮源.mineral salt⽆无机盐
macroelement⼤大量量元素.trace element microelement微量量元素growth factor⽣生⻓长因⼦子.precursor前体
accelerant促进剂.fed medium补料料培养基
agar琼脂粉.contaminated microbe杂菌contamination污染.phage噬菌体
disinfection消毒.sterilization灭菌
pathogen病原微⽣生物.filtration sterilization过滤灭菌
filter过滤介质
VVM空⽓气流量量（单位时间单位体积内通⼊入的标准状况下的空⽓气体积）
primary culture原代培养.passage culture传代培养
solid surface culture固体表⾯面培养.liquid submerged culture液体深层培养immobilized culture固定化培养.high cell density culture⾼高密度培养intermittent opration间歇式操作.discontinuous operation不不连续培养semi-continuous operation半连续培养.batch operation分批式操作
fed batch operation补料料-分批式（流加）操作.chemostat恒化器器
MPa罐压.dissolved oxygen DO溶解氧
cell concentration菌体浓度.fermentation heat发酵热
production heat产⽣生热.loss heat散失热
biological heat⽣生物热.agitation heat搅拌热
evaporation heat蒸发热.sensible heat显热
radiant heat辐射热.oxygen supply供氧
oxygen consumption耗氧.dissolved oxygen coefficient溶解氧系数oxygen transfer rate OTR氧传递速率.oxygen uptake rate OUR摄氧速率ventilation通⽓气.respiratory intensity呼吸强度
oxygen saturation concentration氧饱和浓度.respiratory quotient RQ呼吸熵critical oxygen concentration临界氧浓度.fill补料料
withdraw放料料.foam泡沫
defoaming agent消沫剂.surfactant表⾯面活性剂
dispersant分散剂.emulsifier乳化剂
inertcarrier惰性载体.antibiotic抗⽣生素
carbenicillin羧苄⻘青霉素/⻘青霉素G
6-aminopenicillanic acid6-APA6-氨基⻘青霉烷酸.cephalosporin C CPC头孢菌素C erythromycin红霉素.amino acid氨基酸
hybridomn杂交瘤.vitamin维⽣生素
recombinant DNA technology重组DNA技术.recombinant DNA products rDNA制品plasmid质粒.replicon复制⼦子
promoter启动⼦子.terminator终⽌止⼦子
multiple cloning site MCS多克隆隆位点.transferability转移性incompatibility不不相容性.cloning vector克隆隆载体expression vector表达载体.shuttle vector穿梭载体intergration vector整合载体.inclusion body包涵体
yeast酵⺟母.genetic engineering strain基因⼯工程菌yeast intergration plasmid YIP酵⺟母整合载体
yeast episomal plasmid YEP酵⺟母附加载体
yeast centromere plasmid YCP酵⺟母着丝粒载体
centromere sequence CEN着丝粒序列列
autonomously replicating sequences ARS⾃自主复制序列列
yeast replicating plasmid YRP酵⺟母复制质粒
polymerase chain reaction PCR聚合酶链式反应
reverse transcription PCR RT-PCR反转录PCR
complementary DNA cDNA
avian myeloblastosis virus AMV禽源成髓细胞瘤病毒
moloney murine leukemia virus MMLV⿏鼠源败⾎血病毒莫勒勒尼株
diethyl pyrocarbonate DEPC焦碳酸⼆二⼄乙酯.denaturation变性
annelling退⽕火.extension链延伸
restriction endonuclease限制性核酸内切酶.ligase连接酶
recombinant重组⼦子.interferon IFN⼲干扰素recombinant human interferon rhIFN
tricarboxylic acid cycle TCA循环三羧酸循环
pentose phosphate pathway PPP磷酸戊糖途径.glycosylation糖基化
apoptosis凋亡.diploid cell⼆二倍体
primary cell原代细胞.passage cell传代细胞
immortal cell永久细胞系.Chinese hamster ovary CHO中国仓⿏鼠卵卵巢DHFR⼆二氢叶酸还原酶.methotrexate MTX甲氨蝶呤baby hamster kidney BHK幼仓⿏鼠肾脏dicistron双顺反⼦子
long terminal repeat sequences LTRS逆转录病毒的⻓长末端重复序列列
cytomegalovirus CMV⼈人巨噬病毒.ubiquitin泛素蛋⽩白
bovine growth hormone.BGH⽜牛⽣生⻓长素.toppoisomerase拓拓扑异构酶internal ribosome entry site IRES核糖体进⼊入位点.serum⾎血清
minimum essential medium MEM basal medium Eagle’s BME Dulbecco’s modified Eagle’s medium DMEM
Glasgow’s modified Eagle’s medium GMEM
Joklik’s Park Memorial Eagle’s medium JMEM
Roswell Park Memorial Institute RPMI
serum-free medium SEM⽆无⾎血清培养基.buffer solution缓冲液
balance saline solution BSS平衡盐溶液
monolayer anchorage-dependent culture单层贴壁培养.suspension culture悬浮培养microcarrier微载体.microencapsulation method微囊法phosphonate buffer solution PBS磷酸盐缓冲液.scale-down缩⼩小erythropoietin EPO红细胞⽣生成素.luria bertani LB recombinant human erythropoietin rhEPO重组⼈人红细胞⽣生成素
synthon合成⼦子.synthetic equivalent合成等价物protocol solvent质⼦子性溶剂.micronization微晶化
catalyst催化剂.phase transfer catalyst相转移催化剂TEBAC三⼄乙基苄基氯化铵Mokosza催化剂
TO/CMAC三⾟辛基甲基氯化铵Starks催化剂.Brandstrom催化剂四丁基硫酸氢铵chirality⼿手性.enantiomers对应异构体configuration构型.chiral drug⼿手物
enantiomeric excesses对映体过量量e.e.%.restrosynthesis追溯求源法resolution拆分.omeprazole奥美拉唑paclitaxel,Taxol紫杉醇.cephalosporin C CPC头孢菌素7-aminocephalosporanic acid7-ACA7-氨基头孢烷酸.cefalexin头孢氨苄tetrahydrofuran THF四氢呋喃.quality by design QbD质量量源于设计process analysis technology PAT过程分析技术
quality target product profile QTPP⽬目标产品质量量概况
critical material attribute CMA关键物料料属性
critical process parameter CPP关键⼯工艺参数
normal operation range NOR正常操作区间
proven acceptable range PAR可接受的区间
critical quality attribute CQA关键质量量属性bioreactor⽣生物反应器器
key process parameter KPP重要⼯工艺参数.fermenter发酵罐complete stirred tank reactor CSTR全混流反应器器.yield得率
piston fluid reactor PFR平推流反应器器.titer效价
stirred tank reactor STR搅拌罐.scale-up放⼤大
fixed bed reactor固定化床反应器器.draft tube导流筒
packed bed reactor PBR填充床反应器器.bubble column⿎鼓泡塔fluidized bed reactor FBR流化床反应器器.air-lift reactor⽓气升式反应器器disk and turbine impeller涡流式搅拌桨.process validation⼯工艺验
证marine style impeller推进式搅拌桨.process design⼯工艺设计process mass intensity PMI过程质量量强度.process qualification⼯工艺确认reaction mass efficiency RME反应质量量效率
standard operation procedure SOP标准操作规程.
continued process verification⼯工艺核实
biochemical oxygen demand BOD⽣生化需氧量量.total nitrogen TN总氮chemical oxygen demand COD化学需氧量量.suspended subatance SS悬浮物mixed liquor suspended solids MLSS混合液悬浮固体
total organic carbon TOC总有机碳.sludge volume SV污泥泥沉降⽐比sludge volume index SVI污泥泥指数
piping&instrument diagram PID⼯工艺控制流程图

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