Blister pack
Tablets in a blister pack
From Wikipedia, the free encyclopedia
Blister pack  is a term for several types of pre-formed
plastic packaging used for small consumer goods.
The two primary components of a blister pack are the
cavity or pocket made from a "formable" web, either
plastic or aluminium - and the lidding, made from paper,
carton, plastic or aluminium. The "formed" cavity or
pocket contains the product and the "lidding" seals the
product in the package.
Contents
1 Uses
1.1 Unit dose packaging of
Pharmaceuticals
1.2 Consumer goods
1.3 Medical Blisters
2 Production - Pharmaceutical blister packs
2.1 Thermoforming
2.2 Cold forming
3 Materials - Pharmaceutical blister packs
3.1 PVC
3.2 PCTFE
3.3 COC
4 See also
5 References Uses
Unit dose packaging of Pharmaceuticals
Blister packs are commonly used as unit-dose packaging for pharmaceutical tablets, capsules or lozenges. Blister packs can provide barrier protection for shelf life requirements, and a degree of tamper resistance. In the USA, blister packs are mainly used for packing physician samples of drug products, or for Over The Counter (OTC) products in the pharmacy. In other parts of the world, blister packs are the main packaging type since pharmacy dispensing and re-packaging are not common. A series of blister cavities is sometimes called a blister card or blister strip as well as blister pack. In some parts of the world the blister pack is known as a Push-Through-Pack (PTP). The main advantages of unit-dose blister packs over other methods of packing pharmaceutical products are the assurance of product/packaging integrity (including shelflife) of each individual dose and the possibility to create a
A typical blister-packaged consumer good
A clamshell-packaged action figurepliance pack or calendar pack by printing the days of the week above each dose. Blister packs also hinder the use of OTC drugs in the manufacture of illegal drugs.
Blister packs are created by means of a form-fill-seal process at the pharmaceutical company or
designated contract packer. A form-fill-seal process means that the blister pack is created from rolls of flat sheet or film, filled with the pharmaceutical product and closed (sealed) on the same equipment.Such equipment is called a blisterline.
Blister packs consist of two principal components : 1) a formed base web creating the cavity inside which the product fits and 2) the lidding foil for dispensing the product out of the pack. There are two types of forming the cavity into a base web sheet: thermoforming and cold forming.
Consumer goods
Other types of blister packs consist of carded packaging where
goods such as toys, hardware, and electrical items are contained
between a specially made paperboard card and clear pre-formed
plastic such as PVC. The consumer can easily examine the
product through the transparent plastic. The plastic shell is
vacuum-formed around a mold so it can contain the item snugly.
The card is brightly colored and designed depending on the item
inside, and the PVC is affixed to the card using heat and
pressure to activate an adhesive (heat seal coating) on the blister
card. The adhesive is strong enough so that the pack may hang
on a peg, but weak enough so so that the package can be easily
opened. Sometimes, with large items, the card has a perforated
window for access.
A more secure package is known as a clamshell. It is often used
to deter package pilferage for small high-value items, such as
consumer electronics. It consists of either two pre-formed plastic
sheets or one sheet folded over onto itself and fused at the edges.
They are usually designed to be difficult to open by hand so as
to deter tampering. A pair of scissors or a sharp knife is often
required to open them (although often coming in the same
package). Care must be used to safely open some of these
packages, as 6,000 Americans are sent to the emergency room
each year by opening them.[1] [2] Wrap rage is sometimes the
result.Medical Blisters
Medical Blister trays differ from Pharmaceutical blister packs in
that these are not push-through packs. The thermoformed base web is made of a thicker plastic sheet, generally between 500µ
to 1000µ and can not be collapsed, thus forming a solid tray.
The lidding film provides a peel-open feature and is generally porous to allow sterilization. Such medical blister packs are used for medical devices, used in hospitals.
Production - Pharmaceutical blister packs
Thermoforming
In the case of thermoforming, a plastic film or sheet is unwound from the reel and guided though a pre-heating station on the blister line. The temperature of the pre-heating plates (upper and lower plates) is such that the plastic will soften and become pliable. The warm plastic will then arrive in a forming station where a large pressure (4 to 8 bar) will form the blister cavity into a negative mold. The mold is cooled such that the plastic becomes rigid again and maintains its shape when removed from the mold. In case of difficult shapes, the warm film will be physically pushed down partially into the cavity by a "plug-assist" feature. Plug-assist results in a blister cavity with more uniform wall distribution and is typically used when the cavity size and shape is larger then a small tablet.
Cold forming
In the case of cold forming, an aluminum-based laminate film is simply pressed into a mold by means
of a stamp. The aluminum will be elongated and maintain the formed shape. In the industry these blisters are called cold form foil (CFF) blisters. The principal advantage of cold form foil blisters is that the use of aluminum offers a near complete barrier for water and oxygen, allowing an extended product expiry date. The principal disadvantages of cold form foil blisters are: the slower speed of production compared to thermoforming; the lack of transparency of the package (a therapy compliance disadvantage); and the larger size of the blister card (aluminum can not be formed with near 90 degree angles).
Materials - Pharmaceutical blister packs
PVC
The most basic material for the forming web is PVC or Polyvinyl Chloride. The principal advantages of PVC are the low cost and the ease of thermoforming. The main disadvantages are the poor barrier against moisture ingress and oxygen ingress; moreover PVC has a negative environmental connotation due to its chlorine content. In the case of blister packaging the PVC sheet does not contain any plasticizer and is sometimes referred to as Rigid PVC or RPVC. In the absence of plasticizers, PVC blisters offer structural rigidity and physical protection for the pharmaceutical dosage
form. On the other hand, the blister cavity must remain accessible by the push-through effect and the formed web may not be too hard to collapse when pressed upon; for this reason the PVC sheet thickness is typically chosen between 200µ to 300µ depending on the cavity size and shape. Most PVC sheets for pharmaceutical blisters are 250µ or 0.250 mm in thickness. Typical values for the Water Vapor Transmission Rate (WVTR or MVTR) of a 250µ PVC film are around 3.0 g/m2/day measured at
38°C/90%RH and the Oxygen Transmission Rate (OTR) is around 20 cc/m2/day. In order to overcome the lack of barrier properties of PVC film, it can be coated with PVDC or laminated to PCTFE or COC to increase the protective properties. Multi-layer blister films based on PVC are often used for pharmaceutical blister packaging, whereby the PVC serves as the thermoformable backbone of the structure. Also, the PVC layer can be colored with pigments and/or UV filters. The European Pharmacopoeia (EP) references the requirements for PVC blister packs for pharmaceutical primary packaging in the monograph EP 3.1.11 "MATERIALS BASED ON NON-PLASTICISED
POLY(VINYL CHLORIDE) FOR CONTAINERS FOR DRY DOSAGE FORMS FOR ORAL ADMINISTRATION". In order to be suitable for pharmaceutical blister packs, the PVC formulation also needs to comply with the US Pharmacopoeia <661>; EU food legislation; US 21.CFR and Japanese fo
od contact requirements.
PCTFE
Polychlorotrifluoro ethylene or PCTFE can be laminated to PVC to obtain very high moisture barrier. Typical constructions used for pharmaceutical products are 250µ PVC film laminated to 15µ-100µPCTFE film. Duplex structures are PVC/PCTFE and triplex laminates are PVC/PE/PCTFE. Deeper cavities can be formed by using the triplex structures with PE. Typical WVTR values are between 0.06 - 0.40 g/m2/day.
COC
Cyclic olefin copolymers (COC) or polymers (COP) can provide moisture barrier to blister packs, typically in multilayered combinations with polypropylene (PP), polyethylene (PE), or glycol-modified polyethylene terephthalate (PETg). Cyclic olefin resins are generally amorphous and are noted for good thermoforming characteristics even in deep cavities, leading some to use COC in blister packaging as a thermoforming enhancer, particularly in combination with semicrystalline resins such as PP or PE. Films can be manufactured via coextrusion or lamination. WVTR values of commercial cyclic olefin-based pharmaceutical blister films typically range from 0.20 to 0.35 g/m2/day at 38C/90%
RH. Unlike PVC and other common pharmaceutical barrier resins, cyclic olefin resins do not contain chlorine or other halogens in their molecular structure, being comprised solely of carbon and hydrogen. Cyclic olefin resins are available which comply with pharmaceutical packaging guidelines in the US, Europe, and Japan.
See also
Heat sealer
Skin pack
editordoesnotcontainamaintype
Ultrasonic welding
Wrap rage
References
1. ^ Packages You Won’t Need a Saw to Open
(imes/2008/11/15/technology/internet/15packaging.html?em)
2. ^ Elliot, V S (22 December 2008). "Ho ho woes: Wrap rage results in lacerations and bad
tempers" (/amednews/2008/12/22/hll21222.htm) . American Medical News. /amednews/2008/12/22/hll21222.htm. Retrieved 4 January 2010.
"Package Type standard"
(/web/20071221113739/v/cder/dsm/drg/Drg00907.htm) .
CDER data standards manual. U.S. Food and Drug Administration. Archived from the original (v/cder/dsm/drg/Drg00907.htm) on 2007-12-21.
/web/20071221113739/v/cder/dsm/drg/Drg00907.htm.
Retrieved 2006-01-21.
Brody A. L, and Marshm K, S, "The Wiley Encyclopedia of Packaging Technology" 1997, ISBN: 0-471-06397-5formatting
Retrieved from "/wiki/Blister_pack"
Categories: Packaging | Pharmaceutical industry
This page was last modified on 3 March 2010 at 12:40.
Text is available under the Creative Commons Attribution-ShareAlike License; additional terms may apply. See Terms of Use for details.
Wikipedia® is a registered trademark of the Wikimedia Foundation, Inc., a non-profit organization.

版权声明：本站内容均来自互联网，仅供演示用，请勿用于商业和其他非法用途。如果侵犯了您的权益请与我们联系QQ:729038198，我们将在24小时内删除。