Drug Discovery and Development ⏹The length of developing a drug from concept to
market is about 10 to 15 years.
⏹The cost of R&D per new drug is US $ 800 million (in
terms of 2000 US dollars), and the cost of per approved new drug for R&D (conducted after approval) increases to nearly US $ 900 million.
1“It is easier to put a rocket on the moon than to discover a new drug, and it (the rocket) also costs less money”
Jean-Pierre Garnier CEO, GSK
The Guardian, 30 July 2005.
(Also on talking to Peter Day, In Business,BBC
Radio 4, 23 June 2005.)
3  A sketch of the drug R&D process The  dream  of  a  medicinal  chemist  is  to  discover  a  new  drug,
but  the  majority  of  medicinal
chemists  in  the  pharmaceutical  industry  spent  all  their  lives  working  on  drug  discovery  and  did  not  have  a  drug  on  the  market.新药研发的过程和高额费用的情况(姜申德29 Aug 2012) I ask Hans Nilsson, the Swedish native who oversees the Waltham site, why it's so hard to hatch a new drug. He walks up to the white board in his office and makes a series of drawings: enzyme, membrane, cell, tissue, organ, mouse, cat, dog, monkey, human, cluster of humans.
为什么做一个新药不容易，Hans Nisson 在
5The initial stage of drug discovery
-hits and leads are identified
Choosing
a disease Choosing a drug target Identifying
a bioassay
Looking for hit and lead compounds The Leads 先导化合物Natural Products (the plant kingdom,
the microbial world, the marine world,
animal sources, venoms and toxins)
Medical Folklorereactive materials studies
Synthetic Compound Libraries
Existing Drugs
And Others These  strange
creatures  from
the  deep  sea
can  offer  novel
chemical
structures  for
drug  discovery.
7
Biodiversity
9

版权声明：本站内容均来自互联网，仅供演示用，请勿用于商业和其他非法用途。如果侵犯了您的权益请与我们联系QQ:729038198，我们将在24小时内删除。