RESUME
PERSONAL DETAILS
Applicant  :            Mrs. Nirali Pandya
Date of Birth  : 1st  July 1985
Sex  : Female
Marital Status  : Married
Nationality  : Indian
Present Address :                        Discipline of Inorganic Materials and Catalysis,
Central Salt and Marine Chemicals Research
Institute (CSMCRI-CSIR), G.B. Marg,
Bhavnagar-364002, Gujarat, India
Ph: +91-9033211373                                                                                                                                                                  Email: *******************, ************************
Ph.D. Thesis Title :          “Studies on the interaction of chiral transition metal complexes with
DNA and protein ”
(Supervisor-Dr. N. H. Khan, Principal  Scientist and Supervisor- Dr.
Sandhya Mishra, Sr. Scientist; and CSIR-Central Salt and Marinereactive materials studies
Chemicals Research Institute, Bhavnagar, Gujarat)
M.Sc. dissertation project : “Molecular Characterization and  Phylogenetic  Analysis  of  genus
Jatropha using RAPD and AFLP Fingerprinting”
(Supervisor-Dr. M. P. Reddy, Sr. Principal Scientist, CSIR-CSMCRI, Bhavnagar, Gujarat, India)
✓ Design and Synthesis of chiral ligands (Monomer, Dimer, Oligomer, Polymer and Dentrimers)
and Synthesis of air/moisture stable chiral metal complexes (Ti, V, Cr, Mn, Cu, Ni, Zn, Fe etc.)
and their characterization by various physico-chemicals methods.
✓ Designing and synthesis of organic ligands that can be used for selective recognition of biological
important ions.
✓ Synthesis of chiral Schiff base metal complexes with potential antioxidant, antibacterial and
anticancer activities for their utilization in pharmaceutical industries.
✓ Assessment  of  chiral  Schiff  base  metal  complexes for  their  binding  and cleavage  activities
with DNA and proteins.
✓ Exploring the antioxidant potentials of various chiral metal complexes protection the human cell
against the free radicals and reactive oxygen species.
✓ Exploring the anticancer potentials of various chiral metal complexes against the cancer cells.
1.  Chemistry:  Metal complex  synthesis and their characterization by using techniques like UV
Spectroscopy, IR Spectroscopy, 13C& 1H NMR, LC-MS, Melting Point, Optical rotation,
CHNS analysis.    2.  Biochemistry:  DNA and protein interaction techniques Like UV/Visible/Fluorescence Spectroscopy,
ACADEMIC QUALIFICATION
Degree
University/Board Subject Year of Passing % of Marks Ph. D
CSMCRI, (CSIR) Bhavnagar Uni., Gujarat, India Biotechnology  2012 Thesis submitted M.Sc.
S. P. University, V. V. Nagar, Gujarat, India Biochemistry 2007 64.8 B.Sc.
S. P. University, V. V. Nagar, Gujarat, India Biochemistry
2005 67.4 RESEARCH  EXPERIENCE/INTEREST  TECHNICAL SKILLS IN RESEARCH
Circular dichorism Spectroscopy, Viscosity study, Electrophoresis- Agarose for DNA cleavage and
Protection, SDS/Native PAGE for protein cleavage, DNA damage studies using COMET assay,
estimation of anti-oxidant activity and anticancer activities.
3.Microbiology:  Sterilization techniques, serial dilution and plating methods, obtaining pure culture
and maintenance, gram staining, antibacterial and antifungal assay.
4.Molecular Biology: DNA and RNA isolation, PCR based techniques: RAPD, AFLP techniques,
Primer designing.
5.Software:  Chem Bio draw, Microsoft origin and  Mestec Nova, statistical analysis.
LIST OF PUBLICATIONS
1.Nirali  Pandya,  Noor-ul  H.  Khan,* K.  Jeya  Prathap, Rukhsana  I. Kureshy, Sayed  H.  R.  Abdi,  Sandhya Mishra and Hari C. Bajaj. DNA binding, antioxidant activity and DNA damage protection of chiral macrocyclic Mn(III) salen complexes. Chirality 2012, Accepted.
2.Nirali  Pandya, Noor-ul  H.  Khan,* K. Jeya  Prathap,  Rukhsana  I.  Kureshy,  Sayed  H.  R.  Abdi,  Sandhya Mishra and Hari C. Bajaj. Synthesis and characterization of chiral dinuclear V(V) Schiff base
complexes:  DNA,  Protein  binding,  cleavage  and  antimicrobial  activity. Organic & Biomolecular chemistry 2012 (communicated).
3. Noor-ul H. Khan,* Nirali Pandya, Nabin C. Maity, Manoj Kumar, Rukhsana I. Kureshy, Sayed H.  R.  Abdi,  Sandhya Mishra,  Satyabrata  Das  and  Hari  C.  Bajaj.  Influence of chirality  of  V(V)  Schiff  base complexes  on  DNA,  BSA  binding  and cleavage  activity. Eur.  J.  Med. Chem. 2011, 46, 5074- 5085.
4.  Noor-ul  H.  Khan,* Nirali  Pandya,  K.  Jeya  Prathap,  Rukhsana  I.  Kureshy,  Sayed  H.    R.  Abdi,  Sandhya  Mishra  and  Hari  C. Bajaj.  Chiral discrimination asserted by enantiomers of Ni(II),  Cu(II)  and  Zn(II)  Schiff  base  complexes  in  DNA  binding,  antioxidant  and  antibacterial  activities.,  Spectrochim. Acta Part A 2011, 81, 199-208.
5.  Noor-ul H. Khan*, Nirali Pandya, Manoj Kumar, Prasanta K. Bera, Rukhsana I. Kureshy, Sayed H. R. Abdi and Hari C. Bajaj. Influence of chirality using Mn(III) salen complexes on DNA binding and antioxidant activity Org. Biomol. Chem. 2010, 8, 4297-4307.
6.  Noor-ul H. Khan*, Nirali Pandya, Rukhsana. I. Kureshy, Sayed. H. R. Abdi, Santosh Agrawal, Hari
C. Bajaj, Jagruti Pandya and Akhshya Gupte. Synthesis Characterization, DNA binding and cleavage studies of chiral Ru(II) salen complexes,. Spectrochimica Acta Part A 2009, 74, 113-119,
7.  Pamidiamarri, D. V. N. S., Nirali Pandya, Reddy, M. P.,* and Radhakrishnan, T. Comparative study of interspecific genetic divergence and phylogenic analysis of genus Jatropha by RAPD and AFLP.  Molecular Biology Reports 2009, 36, 901-907. (M.Sc dissertation work).
8.Nirali  Pandya,  Noor-ul  H.  Khan,* K.  Jeya  Prathap, Rukhsana  I.  Kureshya, Sayed  H.  R.  Abdi,  Sandhya Mishra and Hari C. Bajaj. Radical scavenging activities by novel chiral Cu(II) and Mn(III)  salen complexes. (Under preparation).
CONFERENCES/SYMPOSIUM ATTENDED
1.Nirali Pandya,  N. H. Khan, R. I. Kureshy, S. H. R. Abdi, N. C. Maity, M. Kumar, S. Mishra, S. B.  Das and H. C. Bajaj (2011) Chiral macrocyclic Mn(III)salen complexes for efficient radical scavenging  activity  and  DNA  damage  protection.  Presented  in  “National  Conference  on Chirality”, 2nd-3rdDecember,  The  Maharaja  Sayajirao  University  of Baroda,  Vadodara,  Gujarat, India.
2.Nirali Pandya, N. H. Khan, R. I. Kureshy, S. H. R. Abdi, N. C. Maity, M. Kumar, S. Mishra, S. B. Das a
nd H. C. Bajaj (2009) CT DNA, protein binding and cleavage activity mediated through chiral V(V) salen complexes. Presented in National conference on “Emerging Field in Life Sciences”, 16th-17th November, N. B. Mehta (Valwada) Science College Bordi, Mumbai, India.
3.Attended a conference “XXII Gujarat Science Congress 2008” on 9thMarch (2008), organi zed at Bhavnagar University, Bhavnagar, Gujarat, India.
AWARDS/SCHOLARSHIPS/TRAINING
1.  2008-2012: Recipient of CSIR Network project Project Assistant fellowship.
2. Recipient of I st Prize in oral presentation of a paper entitled “Chiral macrocyc lic Mn(III)salen complexes for efficient radical scavenging activity and DNA damage protection”. Presented in“National Conference on Chirality”, 2nd-3rd December (2011), The Maharaja Sayajirao University of Baroda, Vadodara, Gujarat, India.
3. Recipient  of  I st Prize  in  oral  presentation of  a  paper  entitled “CT  DNA,  protein  binding  and cleavage  activity  mediated  through  chiral  V(V)  salen  complexes”.  Presented in National conference on “Emerging Field in Life Sciences”, 16th-17th November (2009), N.    B. Mehta (Valwada) Science College Bordi, Mumbai, India.
RESEARCH EMPLOYMENT DETAILS
Period Name of Employer Place Position
2008-2012 CSMCRI-CSIR Bhavnagar, Gujarat Project Assistant Level-II (Project) 2012 onwards CSMCRI-CSIR Bhavnagar, Gujarat Senior Research Fellow (CSIR) FOLLOWING EXPERTS MAY BE CONTACTED FOR REFERENCES
Dr. Sandhya Mishra, (Ph.D. Supervisor)
Scientist-E-I, (Biotechnogist & Microbiologist)
Salt and Marine Chemicals Department
Central Salt and Marine Chemical Research Institute
Bhavnagar-364002, Gujarat, India
Email:******************
Dr. N. H. Khan (Ph.D. Supervisor)
Scientist-E-II (Inoganic Chemist)
Discipline of Inorganic Materials and Catalysis
Central Salt and Marine Chemical Research Institute
Bhavnagar-364002, Gujarat, India
Email:****************************************
Dr. R. I. Kureshy (Research collaborator)
Principal Scientist (Organic Chemist)
Discipline of Inorganic Materials and Catalysis
Central Salt and Marine Chemical Research Institute
Bhavnagar-364002, Gujarat, India
Email:********************************************
Lastly, I solemnly declare that the foregoing information is complete and correct to the best of my knowledge.
Place: Bhavnagar, Gujarat  Applicant: Mrs. Nirali Pandya

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