专利名称：PHOTOCLEAVABLE PROTECTING GROUPS AND METHODS FOR THEIR USE
发明人：MCGALL, Glenn, H.,NAM, Ngo, Q.,RAVA,reactive carbonyl species
Richard, P.
申请号：US1998004280
申请日：19980305
公开号：WO98/039348P1
公开日：
19980911
专利内容由知识产权出版社提供
摘要：Novel compounds are provided which are useful as linking groups in chemical synthesis, preferably in the solid phase synthesis of oligonucleotides and polypeptides. These compounds are generally photolabile and comprise protecting groups which can be removed by photolysis to unmask a reactive group. The protecting group has the general formula: Ar-C(R1)(R2)-O-C(O)- wherein: Ar is an optionally substituted fused polycyclic aryl or heteraromatic group or a vinylogous derivative thereof; R1 and R2 are independently H, optionally substituted alkyl, alkenyl or alkynyl, optionally substituted aryl or optionally substituted heteroaromatic, or a vinylogous derivative of the foregoing; and X is a leaving group, a chemical fragment linked to Ar-C(R1)(R2)-O-C(O)- via a heteroatom, or a solid support; provided that when Ar is 1-pyrenyl and R1 and R2 are H, X is not linked to Ar-C(R1)(R2)-O-C(O)- via a nitrogen atom. Preferred embodiments are those in which Ar is a fused polycyclic aromatic hydrocarbon and in which the substituents on Ar, R1 and R2 are electron donating groups. A particularly preferred protecting group is the 'PYMOC' protecting group, pyrenylmethyloxycarbonyl, where Ar is pyrenyl and R1 and R2 are H. Also provided is a method of forming, from component molecules, a
plurality of compounds on a support, each compound occupying a separate predefined region of the support, using the protected compounds described above.
申请人：MCGALL, Glenn, H.,NAM, Ngo, Q.,RAVA, Richard, P.
地址：US,US,US,US
国籍：US,US,US,US
代理机构：MONROY, Gladys, H.
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