专利名称：TRUNCATED CD200
发明人：GORCZYNSKI, Reginald, M.申请号：EP01997506.9
申请日：20011122
公开号：EP1337560B1
truncate delete区别公开日：
20080827
专利内容由知识产权出版社提供
摘要：A truncated form of the full-length, immunosuppression-inducing molecule, CD200, CD200tr, was expressed in CHO cells and the transduced cells used to produce mAbs to CD200tr. These mAbs detect simultaneous expression of full-length CD200 and CD200tr in LPS-stimulated dendritic cells (DCs). Moreover, CHO cells and DCs expressing CD200tr as well as soluble CD200tr are able to inhibit suppression of mixed leucocyte reactions in vitro which follows addition of the soluble form of CD200 (CD200:Fc) in culture, demonstrating that CD200tr is a physiological antagonist of CD200.
申请人：TRILLIUM THERAPEUTICS INC
地址：CA
国籍：CA
代理机构：Harrison Goddard Foote
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