polarisedStructural and biochemical properties of Sept7, a unique septin required for filament formation.
期刊名称： Biological Chemistry
作者： Eldar Zent,Ingrid Vetter,Alfred Wittinghofer
年份： 2011年
期号： 第8-9期
关键词： cytoskeleton;filament;GTP-binding protein;septin;X-ray crystallography
摘要：Septins constitute a family of conserved guanine nucleotide binding proteins found in a wide range of organisms from fungi to mammals. Members of the family share a canonical G-domain with N- and C-terminal extensions. G-domains assemble into hetero-oligomeric complexes which form non-polarised filaments or rings. Linear filaments are formed between the G-domains using either the guanine nucleotide binding site (G interface) or N- and C-terminal extensions (NC interface). Sept7 is a unique among the 13 human septins in that it occupies the ends of hexameric building blocks which as
semble into non-polarised filaments. To gain insight into its particular properties we performed structural and biochemical studies on Sept7. We solved the crystal structure of a Sept7 dimer in the GDP-bound state. The structure and biochemistry
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