Oral GABA treatment downregulates inflammatory responses in a mouse model of rheumatoid arthritis 期刊名称： Autoimmunity
作者： Tian, Jide,Yong, Jing,Dang, Hoa,Kaufman, Daniel L.
年份： 2011年
期号： 第6期
关键词： GABA receptor; GABA; rheumatoid arthritis; T cell; APC; anti-collagen
antibody; autoimmune
modulate摘要：Current treatments for rheumatoid arthritis (RA) have long-term side effects such that new treatments are needed that can safely help manage the disease. There is a growing appreciation that GABA receptors (GABA-Rs) on immune cells provide new targets that can be used to modulate immune cell activity. Here, we show for the first time that activation of peripheral GABA-Rs can inhibit the development of disease in the collagen-induced arthritis (CIA) mouse model of RA. Mice that receiv
ed oral GABA had a reduced incidence of CIA, and those mice that
did develop CIA had milder symptoms. T cells from GABA-treated mice displayed reduced proliferative responses to collagen and their APC had a reduced ability to promote the proliferation of collagen-reactive T cells. Thus, GABA downregulated both T-cell autoimmunity and
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