专利名称：INHIBITOR OF PHOSPHODIESTERASE REACTION
发明人：YAMAZAKI SANAE,SUZUKI
HIDEO,KAMIBAYASHI AKIRA
申请号：JP11746781
申请日：19810727
公开号：JPS57114516A
公开日：
19820716reaction between pvp and amino
专利内容由知识产权出版社提供
摘要：NEW MATERIAL:A compound shown by the formula[R is lower alkyl which may have a substituent group (carboxyl, or amino), aryl]. EXAMPLE:6-[(1-
Methylethyl)thiomethylamino]-9-beta-D-ribofuranosylpurine. USE:An inhibitor of enzyme reaction. By adding the inhibitor to the enzyme reaction, the activity of phosphodiesterase is inhibited, and the decomposition of cyclic AMP is protected. PROCESS:Adenosine is reacted with a compound shown by the formula HS-R(R is methyl, ethyl, propyl, isopropyl, butyl, etc.) and formaldehyde in water, to give a compound shown by the formula. A substituent group is easily introduced to the N<6>-NH2 group of adenosine, the reaction time is usually <=15 hours, and this process is advantageous. A particular pretreatment, for example, the protection of OH in the ribose group of adenosine, etc. is unnecessary, and the process is advantageous.
申请人：KOGYO GIJUTSUIN (JAPAN)
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