专利名称：PROCESSES FOR COUPLING AMINO ACIDS USING BIS-(TRICHLOROMETHYL)
CARBONATE
发明人：FALB, Eliezer,YECHEZKEL, Tamar,SALITRA, Yoseph
申请号：EP99929678.3
申请日：19990711
公开号：EP1097164A1
公开日：reaction between pvp and amino
20010509
专利内容由知识产权出版社提供
摘要：A process of coupling an amino acid residue to a peptide chain which comprises: providing an amino acid residue having a free carboxylic group and blocked amino group, optionally having additional blocked functional side chains; reacting the blocked amino acid with bis- (trichloromethyl) carbonate in a solvent inert to this reaction to obtain an amino acid chloride; neutralizing the free acid with an organic base; adding the resulting suspension containing the amino acid chloride to a compound selected from the group consisting of a peptide having a blocked carboxyl terminus and a free amino terminus, and a peptidyl resin having at least one free amino terminus; and providing reaction conditions enabling the coupling of the amino acid chloride to the peptide to yield a peptide elongated by one amino acid residue, or providing reaction conditions enabling the coupling of the amino acid chloride to the solid support.
申请人：PEPTOR LTD
地址：Kiryat Weizmann 76326 Rehovot IL
国籍：IL
代理机构：Baldock, Sharon Claire 更多信息请下载全文后查看

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