专利名称：Bioreactive allosteric polynucleotides 发明人：Ronald R. Breaker
申请号：US10680067
申请日：20031006
reactive metal公开号：US20050176017A1
公开日：
20050811
专利内容由知识产权出版社提供
摘要：Polynucleotides having allosteric properties that modify a function or configuration of the polynucleotide with a chemical effector and/or physical signal are employed primarily as biosensors and/or enzymes for diagnostic and catalytic purposes. In some preferred embodiments, the polynucleotides are DNA enzymes that are used in solution/suspension or attached to a solid support as biosensors to detect the presence or absence of a compound, its concentration, or physical change in a sample by observation of self-catalysis. Chemical effectors include organic compounds such as amino acids, amino acid derivatives, peptides, nucleosides, nucleotides, steroids, and mixtures of these with each other and with metal ions, cellular metabolites or blood components obtained from biological samples, steroids, pharmaceuticals, pesticides, herbicides, food toxins, and the like. Physical signals include radiation, temperature changes, and combinations thereof.
申请人：Ronald R. Breaker
地址：Guilford CT US
国籍：US
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