专利名称：SYNTHESIS OF 1,4,7-TRIAZACYCLONONANE DERIVATIVES
发明人：MADISON, Stephen, Alan,BATAL, David, John 申请号：EP93914669.0
申请日：19930616
公开号：EP0648211A1
公开日：
19950419
专利内容由知识产权出版社提供
摘要：An improved process is described for obtaining triazacyclononanes, esepcially 1,4,7-trimethyl-1,4,7-triazacyclononame. The first step involves reacting diethylenetriamine (DET) with a sulfonylation agent to form a sulfonamidated DET, in an aqueous medium with an inorganic base. In a second step, but preferably within the same reactor vessel without isolating intermediates, the sulfonamidated DET aqueous mixture is contacted with an aprotic organic solvent in the presence of a cyclizing unit such as ethylene glycol ditosylate or ethylene dibromide, thereby resulting in a cyclized sulfonamidated triamine compound. Thereafter the protecting groups are removed and the amine is alkylated, preferably within a single reaction vessel without isolation of intermediates.
申请人：UNILEVER PLC,UNILEVER N.V.
地址：Unilever House Blackfriars London EC4P 4BQ GB,Weena 455 NL-3013 AL Rotterdam NL
reactor4国籍：GB,NL
代理机构：Kan, Jacob Hendrik, Dr., et al
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