专利名称：NOVEL LONG-ACTING SULPIRIDE TABLET 发明人：NAKAMURA HIDEYUKI
tablet hardness申请号：JP1856686
申请日：19860130
公开号：JPS62178518A
公开日：
19870805
专利内容由知识产权出版社提供
摘要：PURPOSE:To obtain the titled tablet by compounding sulpiride used as a principal drug component with two or more kinds of water-soluble hydrogel-forming substances at specific ratios. CONSTITUTION:Sulpiride of formula used as the principals drug component is added with >=2 kinds of water-soluble hydrogel-forming substances (e.g. gelatin, hydroxypropyl cellulose, methylcellulose, etc.) at a weight ratio of 5:1-1:5 (in total), stirred at a high speed, added with extremely small amount of water or ethyl alcohol and stirred and granulated to easily and economically obtain a long-acting tablet.
A sufficient effect can be attained by using the water or ethyl alcohol at an amount to give fine granules as major part of the granulated product. The obtained granulated product is dried, mixed with a proper amount of a lubricant such as magnesium stearate, talc, etc., and compression- molded with a tableting machine to obtain the objective tablet having a hardness of 6-10kg. The development of side effect caused by excessive administration can be prevented and effective blood concentration can be maintained over a long period by administering the tablet once a day.
申请人：TOHO YAKUHIN KOGYO KK
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