专利名称：NIFEDIPINE-CONTAINING PRESS COATED TABLET AND METHOD OF PREPARING THE
SAME
发明人：YAMANOUCHI, Yuka,FUKUI, Kosuke
申请号：JP2008069828
申请日：20081024
公开号：WO09/054550P1
公开日：tablet press punch and die
20090430
专利内容由知识产权出版社提供
摘要：A sustained release nifedipine-containing press coated tablet, which comprises (A) a core comprising nifedipine and a hydrophilic gel-forming high molecular substance, wherein the dissolution of the nifedipine from the core is designed to be delayed: and (B) an outer shell coating said core, which comprises (i) (a) nifedipine and (b) a disintegration suppression substance comprising a pH-independent water-insoluble polymer, wherein the combined contents of (a) and (b) are in the range of 8 to 22 % by weight based on the total weight of the outer shell, and (ii) a hydrophilic gel-forming high molecular substance selected from cellulose derivatives and polyvinyl alcohols, wherein the content thereof is in the range of 76 to 95 % by weight based on the total weight of the outer shell, which is characterized in that the diameter of said tablet is 7.5 to 8.5 mm, and the thickness thereof is 4.5 to 5.2 mm, and further characterized in that the dissolution rate of nifedipine from said tablet is controlled within a specific range. The tablet of the present invention is miniaturized as compared to the currently-used nifedipine-containing tablets but the dissolution properties and bioavailability of nifedipine therein are not changed.
申请人：YAMANOUCHI, Yuka,FUKUI, Kosuke 地址：JP,JP,JP
国籍：JP,JP,JP
代理机构：TANAKA, Mitsuo
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